Rosuvastatin cocrystals: an attempt to modulate physicochemical parameters

Abstract Background The meager physicochemical properties like low solubility and dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development. In the present work, we explore evolution cocrystal, which may offer synergetic physico-chemical drug. Cocrystal crafting depends on two possible intermolecular interactions; heteromeric homomeric selection compounds with complementary functional groups are contemplated a cause supramolecular synthons in cocrystal formation. Specifically, cocrystals l -asparagine -glutamine molar ratio (1:1) were fabricated by using slow solvent evaporation techniques. Novel rosuvastatin-asparagine (RSC-C) rosuvastatin-glutamine (RSC-G) obtained utilized preliminary investigation further scale-up was done technique. Results novel showed new characteristic powder X-ray diffraction, thermograms differential scanning calorimetry, 1 H liquid FT-NMR spectra, electron microscopy. These results signify establishment interaction within cocrystals. both cocrystals, determined to be engaged hydrogen bond -glutamine. Compared pure rosuvastatin, RSC-C RSC-G 2.17-fold 1.60-fold improved respectively. test that exhibited 1.97-fold 1.94-fold higher than pH6.8 phosphate buffer Conclusion Modulation chemical environment, improvement solubility, demonstrated benefit co-crystallization improve Graphical abstract